KINGS COLLEGE LONDON: Postdoctoral Analysis Affiliate in Radionuclide Physics

Job description

We’re searching for a postdoctoral research affiliate to work on an thrilling 2.5-year mission to reinforce therapeutic choices for sufferers with neuroendocrine tumours. The postdoc will perform mobile and preclinical dosimetry utilizing (and buying if that’s the case desired) knowledge from radiochemical/organic research to create, characterise, and check new molecular radionuclide therapies past beta particle-emitters each in vitro and in vivo in tumour and wholesome cells and tissues. Approaches shall be each as single therapies and together with chemotherapies. Radionuclide imaging research alongside the above knowledge shall be used to tell dosimetry. This put up will work intently with a postdoc with organic experience already in place.

Enchancment of most cancers therapy stays a precedence as 28% of UK deaths are nonetheless attributable to most cancers. Neuroendocrine tumours (NETs), while uncommon, are the exemplar most cancers kind investigated right here as they’re exhausting to deal with. Exterior beam radiotherapy and molecular radionuclide remedy within the type of 177Lu-DOTATATE have enhanced survival for some NET sufferers, however the long-term outlook for many sufferers with superior NETs stays poor.

This work will 1) straight affect future scientific trial design in neuroendocrine most cancers sufferers present process injectable radioactive remedy as a part of their therapy, 2) present proof to transform radionuclide remedy from palliative to healing choices in most cancers, and three) present key building blocks with which to create different efficient radionuclide therapies in addition to impactful mixture therapies.

The work spans mobile and preclinical tumour and health organ dosimetry and might be simply carried out by someone with Monte Carlo modelling expertise and a superb understanding of the fundamental radiation dosimetry rules. Non-obligatory experimental work spans molecular biology, in vitro cell research and preclinical in vivo remedy and radionuclide SPECT and/or PET imaging research, and radiobiology.

On this put up, the profitable candidate will work intently with Dr Terry, her workforce, and industrial collaborators at Perspective Therapeutics, in addition to collaborate with different members of the Division of Imaging Chemistry and Biology and scientists and clinicians at exterior establishments and universities.

The workforce is dedicated to offering an inclusive and supportive setting for all. See  https://www.radlab.uk/workforce and related pages for extra on who we’re and what we do.

This put up shall be provided on a fixed-term contract till 17 September 2026.

It is a full-time put up – 100% full time equal.

Key obligations

• Mobile dosimetry to find out complete cell and nuclear absorbed dose from a spread of radionuclides and radiopharmaceuticals in a spread of cells. 
• Complete physique and organ/tumour-specific dosimetry based mostly on preclinical imaging research and ex vivo biodistribution research. 
• Monte Carlo modeling of vary of situations starting from beta, alpha and Auger-electron emitters to find out radiopharmaceutical-specific necessities from a dosimetry/physics perspective for optimum therapeutic efficacy. 
• Correct and complete document maintaining and sturdy documentation of information acquisition. 
• The job holder will repeatedly collect knowledge, conduct detailed analyses and interpret customary knowledge/info, reporting and presenting findings as acceptable. They may help others to amass or interpret research knowledge, highlighting any points. 
• Take part at conferences (nationwide, worldwide and inside conferences), together with presenting posters and oral displays. 
• Put together manuscripts in collaboration with supervisors and different members of the Division. 
• Design and undertake experiments independently in addition to in collaboration with others. 
• Supervise, prepare, and help junior laboratory members. 
• Collaborate with different members of the division, lending expertise to assist different’s research, the place acceptable.

The above record of obligations might not be exhaustive, and the put up holder shall be required to undertake such duties and obligations as might fairly be anticipated inside the scope and grading of the put up.

Abilities, information, and expertise

Important standards  

1. PhD awarded or close to completion in radiobiology, computational modelling, medical physics or different related subject 
2. BSc (2:1 or above) in Physics or different related subject 
3. Extremely computer literate with coding experience, e.g. MATLAB, Python 
4. Experience in dosimetry programmes and/or Monte Carlo modelling, e.g. MIRD, OLINDA 
5. The power to take particular person accountability for planning and enterprise personal work, in line with scientific and scientific deadlines
6. Abilities in presenting scientific research within the type of papers, posters and oral displays 
7. Improvement of statistical and computational dosimetric strategies if related 
8. Collaborative strategy to scientific research and showcasing honesty and integrity 
9. Self-motivated to undertake scientific research and implement personal initiatives 
10. Experience in analysing in vitro and in vivo knowledge to derive dosimetric parameters

Fascinating standards

1. Postdoctoral expertise in radiobiology or computational modelling 
2. Expertise making use of radiation dosimetry rules  
3. Radiation coaching and information of dealing with and safety of organic and radioactive supplies 
4. Expertise in calibration procedures  
5. Expertise in small animal radionuclide imaging research