Principal Scientist, Preformualtion and Biopharmaceutics

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If you’re a Jazz worker please apply through the Inner Profession website Jazz Prescribed drugs plc (NASDAQ: JAZZ) is a world biopharmaceutical firm whose goal is to innovate to rework the lives of sufferers and their households. We’re devoted to creating life-changing medicines for individuals with critical ailments – usually with restricted or no therapeutic choices. Now we have a various portfolio of marketed medicines and novel product candidates, from early- to late-stage improvement, in neuroscience and oncology. We actively discover new choices for sufferers together with novel compounds, small molecules and biologics, and thru cannabinoid science and progressive supply applied sciences. Jazz is headquartered in Dublin, Eire and has staff across the globe, serving sufferers in almost 75 nations. For extra info, please go to www.jazzpharmaceuticals.com and observe @JazzPharma on Twitter. Temporary Description: The Discovery and Medicinal Chemistry Division at Jazz Pharma is looking for an enthusiastic scientist to hitch the Preformulation & Biopharmaceutics on the Kent Science Park website in Sittingbourne. You’ll work along with different CMC scientists to advance drug candidates from lead optimization to proof of idea. This function designs and executes elaborate experiments for pharmaceutical sciences initiatives and demonstrates resourcefulness in operating a number of actions concurrently, all associated to achievement of targets/targets. Important Features/Tasks Collaborate inside CMC and cross-functional groups because the pre-Formulation lead and actively contribute to deliverables and have interaction in cross-functional technical evaluate and troubleshooting. Ship and oversee the optimization of pre-clinical and scientific formulations by way of rational experimental design, considerate execution, and clear knowledge interpretation. Perform solubility and dissolution experiment to evaluate the soundness and predict the bio-performance of our inside formulations. Establish gaps in inside formulation/biopharmaceutics capabilities and the place applicable lead an effort to implement appropriate applied sciences. Independently arrange solid-form and/or drug product associated specs for CoA Handle, coach and mentor extra junior members of workers. Present clear scientific and technological management to direct studies. Adjust to all related safety and GxP procedures. Plan and prioritise personal, and crew’s work with enter from senior supervisor when required. Contain in CRO’s choice course of. Present an oversight of the partnership Required Data, Abilities, and Talents Hold up to date of present literature and up to date developments in Biopharmaceutics and Formulation applied sciences and instrumentation. Data of the interlink between drug substance crystallisation course of, materials traits and influence on drug product improvement.  Good data of pharmacology/DMPK/Tox ideas and in a position to help these areas from drug product perspective. In a position to interpret complicated technical knowledge. Good data of statistical design of experiments. Workforce participant, in a position to talk clearly (wonderful writing and presentational expertise) Sturdy data and hands-on expertise in drug substance/ drug product characterization is a plus. Data in in silico physiologically-based pharmaceutical fashions to foretell in vivo efficiency of intravenous and oral formulations is a plus Data of related FDA and EMA laws is a plus. Required/Most popular Schooling and Licenses PhD/ Grasp’s/ Bachelor’s diploma in Pharmaceutical Sciences, Chemistry, Materials Sciences or Chemical Engineering, with 4- 6 years related industrial expertise. Jazz Prescribed drugs is an Equal Alternative Employer.
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